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Recent Publications


Ye Q, Lau RK, Mathews IT, Birkholz EA, Watrous JD, Azimi CS, Pogliano J, Jain M, Corbett KD. HORMA domain proteins and a Trip13-like ATPase regulate bacterial cGAS-like enzymes to mediate bacteriophage immunity. Molecular Cell. 2020 Jan 10.

Lau RK, Ye Q, Birkholz EA, Berg KR, Patel L, Mathews IT, Watrous JD, Ego K, Whiteley AT, Lowey B, Mekalanos JJ. Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity. Molecular Cell. 2020 Jan 10.

Grankvist N, Watrous JD, Jain M, Nilsson R. Large-Scale Profiling of Cellular Metabolic Activities Using Deep 13 C Labeling Medium. InMetabolic Flux Analysis in Eukaryotic Cells 2020 (pp. 73-92). Humana, New York, NY.

Salosensaari A, Laitinen V, Havulinna AS, Meric G, Cheng S, Perola M, Valsta L, Alfthan G, Inouye M, Watrous JD, Long T. Taxonomic Signatures of Long-Term Mortality Risk in Human Gut Microbiota. medRxiv. 2020 Jan 1:2019-12.

Palmu J, Watrous JD, Mercader K, Havulinna AS, Lagerborg KA, Salosensaari A, Inouye M, Larson MG, Rong J, Vasan RS, Lahti L. Eicosanoid Inflammatory Mediators Are Robustly Associated with Blood Pressure in the General Population. medRxiv. 2020 Jan 1.

Roci I, Watrous JD, Lagerborg KA, Jain M, Nilsson R. Mapping metabolic oscillations during cell cycle progression. bioRxiv. 2020 Jan 1.


Wollam J, Riopel M, Xu YJ, Johnson AM, Ofrecio JM, Ying W, El Ouarrat D, Chan LS, Han AW, Mahmood NA, Ryan CN. Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance. Diabetes. 2019 Jul 1;68(7):1415-26.

Watrous JD, Niiranen TJ, Lagerborg KA, Henglin M, Xu YJ, Rong J, Sharma S, Vasan RS, Larson MG, Armando A, Mora S. Directed non-targeted mass spectrometry and chemical networking for discovery of eicosanoids and related oxylipins. Cell chemical biology. 2019 Mar 21;26(3):433-42.

Le VT, Knowlton KU, McCubrey RO, Knight S, Jain M, Watrous JD, Dao K, Najhawan M, Bair TL, Horne BD, Muhlestein JB. Higher Plasma EPA, EPA/AA and DHA Levels Are Associated With Lower Incident MACE Both in Those With and Without Angiographic CAD. Circulation. 2019 Nov 19;140(Suppl_1):A11700-.

Harris LA, Kayser BD, Cefalo C, Marini L, Watrous JD, Ding J, Jain M, McDonald JG, Thompson BM, Fabbrini E, Eagon JC. Biliopancreatic diversion induces greater metabolic improvement than Roux-en-Y gastric bypass. Cell metabolism. 2019 Nov 5;30(5):855-64.

Le VT, Knowlton KU, Jain M, McCubrey RO, Knight S, Najhawan M, Dao K, Watrous J, Bair TL, Horne BD, Muhlestein JB. Does Supplementation to Higher Plasma Omega-3 Levels Predispose to Prostate Cancer? Results From the Intermountain INSPIRE Biobank Registry. Circulation. 2019 Nov 19;140(Suppl_1):A13187-.

Lagerborg KA, Watrous JD, Cheng S, Jain M. High-throughput measure of bioactive lipids using non-targeted mass spectrometry. InMetabolic Signaling 2019 (pp. 17-35). Humana Press, New York, NY.

Demler O, Liu Y, Watrous J, Gibson H, Lagerborg K, Dashti H, Heath M, Camargo CA, Harris WS, Wohlgemuth JG, Najhawan M. Effects of Marine Omega-3 Supplementation on Fatty Acids and Bioactive Lipids and Associations With Risk of Cardiovascular Disease: Secondary Analysis From the Randomized Vitamin D and Omega-3 Trial (VITAL). Circulation. 2019 Nov 19;140(Suppl_1):A13189-.

Roci I, Watrous JD, Lagerborg KA, Lafranchi L, Lindqvist A, Jain M, Nilsson R. Mapping metabolic events in the cancer cell cycle reveals arginine catabolism in the committed SG2M phase. Cell reports. 2019 Feb 12;26(7):1691-700.

Kantz ED, Tiwari S, Watrous JD, Cheng S, Jain M. Deep Neural Networks for Classification of LC-MS Spectral Peaks. Analytical chemistry. 2019 Sep 4;91(19):12407-13.

McCubrey RO, Le VT, Watrous J, Najhawan M, Dao K, Horne BD, Anderson JL, Knowlton KU, Jain M, Knight S. Predictive Ability of Machine Learning Models for High-Grade Coronary Artery Disease Using Free Fatty-Acid Metabolites. Circulation. 2019 Nov 19;140(Suppl_1):A11950-.

Antonelli J, Claggett BL, Henglin M, Kim A, Ovsak G, Kim N, Deng K, Rao K, Tyagi O, Watrous JD, Lagerborg KA. Statistical workflow for feature selection in human metabolomics data. Metabolites. 2019 Jul;9(7):143.

Henglin M, Niiranen T, Watrous JD, Lagerborg KA, Antonelli J, Claggett BL, Demosthenes EJ, von Jeinsen B, Demler O, Vasan RS, Larson MG. A Single Visualization Technique for Displaying Multiple Metabolite–Phenotype Associations. Metabolites. 2019 Jul;9(7):128.


Grankvist N, Watrous JD, Lagerborg KA, Lyutvinskiy Y, Jain M, Nilsson R. Profiling the metabolism of human cells by deep 13C labeling. Cell chemical biology. 2018 Nov 15;25(11):1419-27.

Palmu J, Watrous J, Havulinna A, Lagerborg K, Salosensaari A, Lahti L, Ritchie S, Inouye M, Cheng S, Salomaa V, Jain M. Eicosanoid Variation is Strongly Related to Blood Pressure in the General Population. Circulation. 2018 Nov 6;138(Suppl_1):A11001-.


Shin CS, Mishra P, Watrous JD, Carelli V, D’Aurelio M, Jain M, Chan DC. The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility. Nature communications. 2017 Apr 21;8(1):1-1.

Watrous JD, Henglin M, Claggett B, Lehmann KA, Larson MG, Cheng S, Jain M. Visualization, quantification, and alignment of spectral drift in population scale untargeted metabolomics data. Analytical chemistry. 2017 Feb 7;89(3):1399-404.

Lyutvinskiy Y, Watrous JD, Jain M, Nilsson R. A web service framework for interactive analysis of metabolomics data. Analytical chemistry. 2017 Jun 6;89(11):5713-8.

Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D. Clinical and Translational Report. Cell Metabolism. 2017 Jul 5;26:157-70.

Claggett BL, Antonelli J, Henglin M, Watrous JD, Lehmann KA, Musso G, Correia A, Jonnalagadda S, Demler OV, Vasan RS, Larson MG. Quantitative Comparison of Statistical Methods for Analyzing Human Metabolomics Data. arXiv preprint arXiv:1710.03443. 2017 Oct 10.

Cheng S, Shah SH, Corwin EJ, Fiehn O, Fitzgerald RL, Gerszten RE, Illig T, Rhee EP, Srinivas PR, Wang TJ, Jain M. Potential impact and study considerations of metabolomics in cardiovascular health and disease: a scientific statement from the American Heart Association. Circulation: Cardiovascular Genetics. 2017 Apr;10(2):e000032.


Wollam J, Johnson AM, Xu YJ, Jain M, Olefsky JM. Gut microbiome produced N‐formyl peptides act through the receptor FPR1 to modulate insulin secretion and metabolism. Diabetes. 2016 Jun 1;65:A453.

Nilsson R, Jain M. Simultaneous tracing of carbon and nitrogen isotopes in human cells. Molecular BioSystems. 2016;12(6):1929-37.

Sapp V, Jain M, Liao R. Viewing extrinsic proteotoxic stress through the lens of amyloid cardiomyopathy. Physiology. 2016 Jul;31(4):294-9.

Roci I, Gallart-Ayala H, Schmidt A, Watrous J, Jain M, Wheelock CE, Nilsson R. Metabolite profiling and stable isotope tracing in sorted subpopulations of mammalian cells. Analytical chemistry. 2016 Mar 1;88(5):2707-13.

2015 and before (Select Publications)

Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science. 2012 May 25;336(6084):1040-4.

Calvo S, Jain M, Xie X, Sheth SA, Chang B, Goldberger OA, Spinazzola A, Zeviani M, Carr SA, Mootha VK. Systematic identification of human mitochondrial disease genes through integrative genomics. Nature genetics. 2006 May;38(5):576-82.

Sharma S, Quintana A, Findlay GM, Mettlen M, Baust B, Jain M, Nilsson R, Rao A, Hogan PG. An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca 2+ entry. Nature. 2013 Jul;499(7457):238-42.

Nilsson R, Jain M, Madhusudhan N, Sheppard NG, Strittmatter L, Kampf C, Huang J, Asplund A, Mootha VK. Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer. Nature communications. 2014 Jan 23;5(1):1-0.

Knoechel B, Roderick JE, Williamson KE, Zhu J, Lohr JG, Cotton MJ, Gillespie SM, Fernandez D, Ku M, Wang H, Piccioni F. An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia. Nature genetics. 2014 Apr;46(4):364-70.

Jain M, Brenner DA, Cui L, Lim CC, Wang B, Pimentel DR, Koh S, Sawyer DB, Leopold JA, Handy DE, Loscalzo J. Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. Circulation research. 2003 Jul 25;93(2):e9-16.

Jain M, Cui L, Brenner DA, Wang B, Handy DE, Leopold JA, Loscalzo J, Apstein CS, Liao R. Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase. Circulation. 2004 Feb 24;109(7):898-903.

Luongo TS, Lambert JP, Yuan A, Zhang X, Gross P, Song J, Shanmughapriya S, Gao E, Jain M, Houser SR, Koch WJ. The mitochondrial calcium uniporter matches energetic supply with cardiac workload during stress and modulates permeability transition. Cell reports. 2015 Jul 7;12(1):23-34.

Sheppard NG, Jarl L, Mahadessian D, Strittmatter L, Schmidt A, Madhusudan N, Tegnér J, Lundberg EK, Asplund A, Jain M, Nilsson R. The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation. Scientific reports. 2015 Oct 13;5(1):1-1.